

The burden of latent multidrug-resistant tuberculosis
In the past 10 years, there has been renewed interest in the early phases of the natural history of tuberculosis.Estimates suggest that around 25% of the world's population could have latent tuberculosis infection,5–10% of whom will develop active disease during their lifetime(10% annually among people with HIV).Failure to implement effective tuberculosis control measures to manage latent infection threatens elimination goals. Groups at high risk of active tuberculosis are th