Following exposure to tuberculosis and subsequent infection, children often progress to tuberculosis disease more rapidly than adults. And yet the natural history of tuberculosis in children, as a continuum from exposure to infection and then to disease, is poorly understood. Children are rarely diagnosed with tuberculosis infection in routine care in international settings and few receive tuberculosis infection treatment. In this Personal View, we review the most up-to-date knowledge in three areas of childhood tuberculosis infection—namely, pathophysiology, diagnosis, and treatment. We then outline what is missing in each of these three areas to generate a priority research agenda. Finally

The webinar, LTBI: New guidelines from the WHO; getting away from INH, examines various treatment regimens for latent tuberculosis infection (LTBI) – essential in preventing TB before the disease progresses. Professor Dick Menzies from the Montreal Chest Institute and McGill TB Centre shares what is new in the World Health Organization’s (WHO) guidelines on LTBI, and also discusses alternatives to using isoniazid therapy (INH). Watch the ‘LTBI: New guidelines from the WHO; getting away from INH’ webinar now: https://www.theunion.org/news-centre/news/union-webinar-on-new-latent-tb-infection-guidelines-now-open-access