Enhanced TB Diagnosis in Hospitalized Adults With HIV: Insights from the CASTLE Trial with Emily McLean

For our October episode, we were pleased to welcome Dr Emily MacLean, Research Fellow at the University of Sydney and Associate Investigator at the NHMRC Centre of Research Excellence in Tuberculosis Control. Dr MacLean leads the New Diagnostics Working Group's Biomarkers Taskforce and has contributed to WHO TB diagnostic policies. Her research focuses on TB epidemiology, diagnostics, and implementation, particularly in under-researched populations.

In this session, Dr MacLean discussed the following article:

“Enhanced Tuberculosis Diagnosis With Computer-aided Chest X-ray and Urine Lipoarabinomannan in Adults With HIV Admitted to Hospital (CASTLE Study): A Cluster Randomized Trial”

Read the article here: https://academic.oup.com/cid/article/80/5/1143/7674063 

We explored how enhanced TB diagnostics, including urine LAM tests and AI-assisted chest X-rays, can improve detection in people with HIV and inform better TB control strategies.

Find out more about Emily and her work in the attached poster.